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deaza  (Merck & Co)

 
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    Structured Review

    Merck & Co deaza
    Deaza, supplied by Merck & Co, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/deaza/2%E2%80%99+7+c+deaza+methyladenosine/bio_rxiv__64898__2026__02__23__707037-95-17-19
    Average 86 stars, based on 1 article reviews
    deaza - by Bioz Stars, 2026-11
    86/100 stars

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    Related Articles

    Control:

    Article Title: Field-isolate recombinant tick-borne encephalitis viruses define reporter-stability guidelines for antiviral screening in flaviviruses
    Article Snippet: .. At one-hour post-infection, cells were treated with either DMSO (vehicle control) or a 1:3 serial dilution of 7-deaza-2’-C-methyladenosine (7DMA, Merck) and incubated for 48h before collection of supernatants and cell lysis. .. Nanoluciferase activity was quantified using the Nano-Glo luciferase assay system kit (Promega) and cell viability was assessed by measuring LDH levels in cell lysates with the CytoTox 96 Non-Radioactive Cytotoxicity (Promega).

    Serial Dilution:

    Article Title: Field-isolate recombinant tick-borne encephalitis viruses define reporter-stability guidelines for antiviral screening in flaviviruses
    Article Snippet: .. At one-hour post-infection, cells were treated with either DMSO (vehicle control) or a 1:3 serial dilution of 7-deaza-2’-C-methyladenosine (7DMA, Merck) and incubated for 48h before collection of supernatants and cell lysis. .. Nanoluciferase activity was quantified using the Nano-Glo luciferase assay system kit (Promega) and cell viability was assessed by measuring LDH levels in cell lysates with the CytoTox 96 Non-Radioactive Cytotoxicity (Promega).

    Incubation:

    Article Title: Field-isolate recombinant tick-borne encephalitis viruses define reporter-stability guidelines for antiviral screening in flaviviruses
    Article Snippet: .. At one-hour post-infection, cells were treated with either DMSO (vehicle control) or a 1:3 serial dilution of 7-deaza-2’-C-methyladenosine (7DMA, Merck) and incubated for 48h before collection of supernatants and cell lysis. .. Nanoluciferase activity was quantified using the Nano-Glo luciferase assay system kit (Promega) and cell viability was assessed by measuring LDH levels in cell lysates with the CytoTox 96 Non-Radioactive Cytotoxicity (Promega).

    Lysis:

    Article Title: Field-isolate recombinant tick-borne encephalitis viruses define reporter-stability guidelines for antiviral screening in flaviviruses
    Article Snippet: .. At one-hour post-infection, cells were treated with either DMSO (vehicle control) or a 1:3 serial dilution of 7-deaza-2’-C-methyladenosine (7DMA, Merck) and incubated for 48h before collection of supernatants and cell lysis. .. Nanoluciferase activity was quantified using the Nano-Glo luciferase assay system kit (Promega) and cell viability was assessed by measuring LDH levels in cell lysates with the CytoTox 96 Non-Radioactive Cytotoxicity (Promega).



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    Systems of ordinary differential equations capture the dynamics of on-target DNA cleavage and trimming by Cas12a. A) Schematic models of the ODE systems. Cas12a cleaves the target DNA into PAM-proximal and PAM-distal ends with a staggered cut. The ODE systems detect the rates of formation for all products and the rates of any subsequent trimming. B) On-target substrate DNA cleavage by Cas12a. Curve: Model-fitted depletion of on-target DNA (measured from 5’ tags). N=3. C) On-target NTS products generated by Cas12a. Blue shades: products of cleavage at the indicated distance from the PAM. Curves: Model-fitted fraction of the indicated product (measured from 5’ and 3’ tags). D) On-target TS products generated by Cas12a. Orange shades: products from cleavage at the indicated distance from the PAM. Curves: Model-fitted fraction of the indicated product (measured from 5’ and 3’ tags). Rates for C and D generated from the mean of three independently-fitted biological datasets. E) Complete modelled fractions of Cas12a substrates and products for all DNA ends. Substrate depletion rates are shown in black, NTS products in shades of blue and TS in orange. Thick lines: PAM-proximal ends, thin lines: PAM-distal ends. Fills assist with identifying product curves. F) Model-fitted initial cleavage and cumulative trimming rates for each strand.

    Journal: bioRxiv

    Article Title: Cas12a cleavage and trimming kinetics reveal mismatches as a tool to steer editing

    doi: 10.64898/2026.08.31.748204

    Figure Lengend Snippet: Systems of ordinary differential equations capture the dynamics of on-target DNA cleavage and trimming by Cas12a. A) Schematic models of the ODE systems. Cas12a cleaves the target DNA into PAM-proximal and PAM-distal ends with a staggered cut. The ODE systems detect the rates of formation for all products and the rates of any subsequent trimming. B) On-target substrate DNA cleavage by Cas12a. Curve: Model-fitted depletion of on-target DNA (measured from 5’ tags). N=3. C) On-target NTS products generated by Cas12a. Blue shades: products of cleavage at the indicated distance from the PAM. Curves: Model-fitted fraction of the indicated product (measured from 5’ and 3’ tags). D) On-target TS products generated by Cas12a. Orange shades: products from cleavage at the indicated distance from the PAM. Curves: Model-fitted fraction of the indicated product (measured from 5’ and 3’ tags). Rates for C and D generated from the mean of three independently-fitted biological datasets. E) Complete modelled fractions of Cas12a substrates and products for all DNA ends. Substrate depletion rates are shown in black, NTS products in shades of blue and TS in orange. Thick lines: PAM-proximal ends, thin lines: PAM-distal ends. Fills assist with identifying product curves. F) Model-fitted initial cleavage and cumulative trimming rates for each strand.

    Article Snippet: To tag 3’ ends of dsDNA targets, targets were treated with terminal deoxynucleotidyl transferase (TdT) (Thermo Fisher Scientific) and 7-Propargylamino-7-deaza-ddATP-Cy3 (Jena Bioscience) in 1X TdT reaction buffer (Thermo Fisher Scientific) for 2 hours at 37 °C, then quenched with 50 mM EDTA.

    Techniques: Generated